Jantscher-Krenn E, Zherebtsov M, Nissan C, Goth K, Guner YS, Naidu N, Choudhury B, Grishin A, Ford H, Bode L. The human milk oligosaccharide disialyllacto-N-tetraose prevents necrotising enterocolitis in neonatal rats. Gut 2012; Oct;61(10):1417-25. The human milk oligosaccharide disialyllacto-N-tetraose prevents necrotising enterocolitis in neonatal rats | Gut (bmj.com)Autran CA, Schoterman M, Jantscher-Krenn E , Kamerling J, Bode L. Sialylated galacto-oligosaccharides and 2'-fucosyllactose reduce necrotising enterocolitis in neonatal rats. Br J Nutr. 2016 Jul;116(2):294-9. Sialylated galacto-oligosaccharides and 2′-fucosyllactose reduce necrotising enterocolitis in neonatal rats | British Journal of Nutrition | Cambridge CoreUnderwood MA, Gaerlan S, De Leoz ML, Dimapasoc L, Kalanetra KM, Lemay D, German JB, Mills DA, Lebrilla CB. Human milk oligosaccharides in premature infants: absorption, excretion, and influence on the intestinal microbiota. Pediatr Res. 2015 Dec;78(6):670-7. Human Milk Oligosaccharides in Premature Infants: Absorption, Excretion and Influence on the Intestinal Microbiota (nih.gov)Hascoët J-M ; Chevallier M; Gire C; Brat R; Rozé J-C; Norbert K; Chen Y; Hartweg M; Buncic-Markovic J; Billeaud C. Effect of a liquid supplement containing 2 human milk oligosaccharides (HMOs) in preterm infants: a multi-centered, double-blind, randomized, controlled trial. Abstract at WCPGHAN 2021.

Effects of 2 Human Milk Oligosaccharides

Accumulating evidence suggests that HMOs have important physiologic functions in early newborn development^1-3.
However, in-hospital supplementation of HMOs for preterm infants had not been clinically tested.

A randomized, double-blind, placebo-controlled trial of preterm infants evaluated the effects of 2’FL & LNnT supplementation on feeding tolerance, growth and safety from 7 neonatal units in France⁴.

*HMOs, structurally identical human milk oligosaccharides, not sourced from breast milk

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References

Jantscher-Krenn E, Zherebtsov M, Nissan C, Goth K, Guner YS, Naidu N, Choudhury B, Grishin A, Ford H, Bode L. The human milk oligosaccharide disialyllacto-N-tetraose prevents necrotising enterocolitis in neonatal rats. Gut 2012; Oct;61(10):1417-25. The human milk oligosaccharide disialyllacto-N-tetraose prevents necrotising enterocolitis in neonatal rats | Gut (bmj.com)
Autran CA, Schoterman M, Jantscher-Krenn E , Kamerling J, Bode L. Sialylated galacto-oligosaccharides and 2'-fucosyllactose reduce necrotising enterocolitis in neonatal rats. Br J Nutr. 2016 Jul;116(2):294-9. Sialylated galacto-oligosaccharides and 2′-fucosyllactose reduce necrotising enterocolitis in neonatal rats | British Journal of Nutrition | Cambridge Core
Underwood MA, Gaerlan S, De Leoz ML, Dimapasoc L, Kalanetra KM, Lemay D, German JB, Mills DA, Lebrilla CB. Human milk oligosaccharides in premature infants: absorption, excretion, and influence on the intestinal microbiota. Pediatr Res. 2015 Dec;78(6):670-7. Human Milk Oligosaccharides in Premature Infants: Absorption, Excretion and Influence on the Intestinal Microbiota (nih.gov)
Hascoët J-M ; Chevallier M; Gire C; Brat R; Rozé J-C; Norbert K; Chen Y; Hartweg M; Buncic-Markovic J; Billeaud C. Effect of a liquid supplement containing 2 human milk oligosaccharides (HMOs) in preterm infants: a multi-centered, double-blind, randomized, controlled trial. Abstract at WCPGHAN 2021.

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Effects of a liquid supplement containing 2’FL & LNnT in preterm infants

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Effects of a liquid supplement containing 2’FL & LNnT in preterm infants

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